Monday, May 04, 2026

 

THE THRUST OF THE SPORT - A SMALL COLLECTION OF POETRY, MAY 4, 2026

DONOVAN BALDWIN
BY DONOVAN BALDWIN


the thrust of the sport

so delightfully displayed

upon such sinful snow


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fabric cannot hide

the thrust of her fantasies

displayed in textures


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she would not deny

confessed all her sins to me

love's beautiful sins


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how beautiful you are

resting in my mind's images

pleasured by poetic passions

and most intimate desires

for constant loving contact

most sacredly sensual


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she wanted to love

and to be loved in return

and at last she was


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in love each one is all

and all are to be loved

there's no sin in that


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told her wild desires

afraid i could not love her

i loved her for them


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she's most visible

a center of attention

among his desires


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not sure she could reach

then body swept with wonder

as desires trembled


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she's desired the strange

the most daring adventures

with him at her side


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she awaits his words

prepared to obey poems

touching her inside


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does she dare declare

what his words have done to her

having seduced her


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sometimes she regrets

that history's sands are so dry

causing her own rain


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in riptides of lust

swept away by her desires

his hand held tightly


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she is full inside

taken by her lover's touch

words spill into her


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Do you still bathe,

With the candles lit,

Scented oils in the water,

Erotic poetry upon your lips,

Prurient pleasures neath your hand

Stirred by your flickering fingertips?


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opens her flower

beckons him to come inside

taste her warm nectar


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lovers without music

dancing in the night's silence

hearing all through touch


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her eyes meeting mine

both of us blushing our way

with understanding


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till he came to her

she never knew she wanted

so many pleasures


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i desire too much

lifetime spent seeking someone

who could give me that


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to whom the art is all

soul and spirit must be

explored and shared

and the inner artist

must be naked and

completely exposed

because that

is the art


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time spent watching you

precious treasures you reveal

dancing before me


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spoke poems to you

the words simmered on my lips

as you tasted them

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arms in freedom's flight

amateur ballerina

posed almost en pointe

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she awaits my words

praising present and future

the past's vibrations

-----

goddess discovered

bares herself to wind and wave

dear nature revealed

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similar hearts lost

separate by fate and age

meant for each other

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spreads petals for me

this lovely cinnamon rose

most treasured blossom

a treasured blossom

i watch this cinnamon rose

spread petals for me

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she comes in my dreams

bringing words i cannot hear

touches i can't feel

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thought of you again

remembered a museum

you and i held hands

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don't deny your sins

ecstatic and erotic

such pleasing secrets

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be bold with your words

always speak the strength of love

reveal your desires

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love stripped down to words

satin sins upon your skin

poetic orgy

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slowly his words trace

naked contours of her mind's...

erogenous zones

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oh that younger me

who went places and did things

loving adventures

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In my absences you are present,

In my lacks you are my necessity,

In my wants you are my wishes,

In my days you are the hours,

In my hours you are he minutes

In my minutes you are the seconds

In my any you are my all.

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many before me

have known your love's pleasures

preparing you for me

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more than a garden

she is a landscape of love

desire's flower bed

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all that we have done

all that we desire to do

sanctified sinners

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i've lived a sinful man

damned for having loved too much

forgiving others like me

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we met two strangers

in this land where love commands

and are united

-----

aphrodite's daughter

touched by a sanctified past

a modern goddess

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noli me tangere

for gods have forsaken me

here in this strange land

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does she wear the art

or is she herself the art

in my mind's museum


Another interpretation...


not just what she wears

she herself the objet d'art

priceless in his eyes

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this urgent flower

blossom aching for release

breathless with her love

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innocence tempted

by the sexual tensions

of mutual needs

-----

a foolish mistake

once i gave my heart away

and she destroyed it

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two bodies coupling

a scene of carnal innocence

sinless intercourse

-----

never felt before

this desire for something strange

new way of loving

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a timeless woman

she reveals and exposes

illuminates the past

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someone to hold her

to caress that empty space

that longs to be touched

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steps out of the past

winsome and wind kissed woman

parasol in hand

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many eyes on her

she saw the poet watching

knew he could see her

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our secrets exposed

our naked thoughts on display

our minds undressed


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first time she kissed her

in a daring departure

into secret dreams

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naked flesh and thoughts

honest exposure of truth

a restricted art

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beauty beyond words

rose glows in sun and shadow

blushing cinnamon


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Interested in your health? You might enjoy Nitric Oxide And The Endothelium.


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Thursday, April 30, 2026

 

NITRIC OXIDE AND THE ENDOTHELIUM

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Nitric oxide (NO) is a colorless, odorless gas that revolutionized our understanding of cardiovascular physiology. Once dismissed as a mere environmental pollutant, it was later revealed to be the "endothelial-derived relaxing factor" (EDRF), a discovery that earned Robert Furchgott, Louis Ignarro, and Ferid Murad the Nobel Prize in Physiology or Medicine in 1998 (The Nobel Prize in Physiology or Medicine 1998 - Presentation Speech, n.d.).

The Vital Role of the Endothelium

The endothelium is a single layer of cells lining the interior surface of blood vessels. Far from being a passive barrier, it is a highly active organ that regulates vascular homeostasis by balancing the production of vasodilators and vasoconstrictors (Frontiers, 2022).

Nitric oxide is the endothelium's most critical signaling molecule. It is synthesized by the enzyme endothelial nitric oxide synthase (eNOS) using the amino acid L-arginine and oxygen as substrates, alongside essential cofactors like tetrahydrobiopterin (BH4) (Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase, 2002; Cellular regulation of endothelial nitric oxide synthase, 2001).

Key Functions of Nitric Oxide

Nitric oxide exerts a variety of protective effects on the cardiovascular system:

  • Vasodilation: NO diffuses into the underlying vascular smooth muscle cells, activating the enzyme guanylate cyclase. This increases cyclic GMP levels, leading to muscle relaxation and vessel widening (The Nobel Prize in Physiology or Medicine 1998 - Press release, n.d.).

  • Anti-thrombotic Effects: It inhibits platelet aggregation and adhesion, preventing the formation of blood clots (Frontiers, 2021).

  • Anti-inflammatory Action: NO prevents the adhesion of white blood cells (leukocytes) to the vessel wall, a key early step in inflammation and atherosclerosis (PubMed, 2020).

  • Antiproliferative Effects: It limits the overgrowth of smooth muscle cells, which helps prevent the narrowing of arteries (Frontiers, 2022).


Endothelial Dysfunction: When NO Fails

Endothelial dysfunction is defined primarily by a reduced bioavailability of nitric oxide (PubMed, 2020). When the endothelium cannot produce enough NO, or when NO is rapidly neutralized by reactive oxygen species (ROS), the vascular balance shifts toward a "pro-thrombotic" and "pro-inflammatory" state (Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis, 2017).

The Phenomenon of "eNOS Uncoupling"

Under conditions of high oxidative stress—such as hypertension, diabetes, or smoking—the eNOS enzyme can become "uncoupled." Instead of producing life-sustaining nitric oxide, the uncoupled enzyme produces superoxide, a harmful free radical that further damages the vessel wall (Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis, 2017).

ConditionImpact on Nitric OxideVascular Result
Healthy EndotheliumHigh NO BioavailabilityDilated, flexible, and protected vessels.
Oxidative StressNO neutralization by ROSConstriction, inflammation, and stiffening.
eNOS UncouplingSuperoxide productionAccelerated plaque formation (Atherosclerosis).

Clinical Relevance and Future Directions

Maintaining nitric oxide levels is a cornerstone of modern cardiovascular therapy. Common medications like ACE inhibitors and statins are known to improve endothelial function partly by increasing NO production or reducing its breakdown (Nitric Oxide, Atherosclerosis and the Clinical Relevance of Endothelial Dysfunction, 2003).

Current research as of 2026 is focusing on "NO-donors" and therapies that can specifically re-couple eNOS to restore the natural protective shield of our arteries (Frontiers, 2026).

References

Frontiers. (2022). Endothelial dysfunction due to the inhibition of the synthesis of nitric oxide: Proposal and characterization of an in vitro cellular model. Frontiers in Physiology. https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.978378/full

Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. (2002). American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 280(2). https://journals.physiology.org/doi/abs/10.1152/ajpregu.00323.2002

Nitric Oxide and Endothelial Dysfunction. (2020). Critical Care Clinics, 36(2), 307–321. https://doi.org/10.1016/j.ccc.2019.12.009

The Nobel Prize in Physiology or Medicine 1998 - Press release. (n.d.). NobelPrize.org. https://www.nobelprize.org/prizes/medicine/1998/press-release/

Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis. (2017). Circulation Research, 120(4), 713-735. https://www.ahajournals.org/doi/10.1161/circresaha.116.309326


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If you enjoyed this article, you might also enjoy Boosting the "Miracle Molecule": How to Increase Nitric Oxide Naturally

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